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What Is Cannabicyclol (CBL)?

Ethan Parker

Written by: Ethan Parker

Updated on December 22, 2023

What is Cannabicyclol (CBL) 2

The roster of cannabinoids garnering attention from the global research community is constantly expanding. Among them, Cannabicyclol (CBL) has recently emerged as a subject of interest, captivating scientists with its distinctive structure and promising therapeutic qualities. CBL could represent a crucial piece in the cannabinoid puzzle, potentially enhancing the entourage effect and significantly broadening our comprehension of cannabis’s capabilities.

In this informative guide, you’ll discover the essence of CBL, stay updated with the latest advancements in CBL research, and understand how it stands in comparison to other cannabinoids. Furthermore, you’ll get insights into the available CBL products and prepare yourself for the upcoming wave of interest in Cannabicyclol.

What Is Cannabicyclol (CBL)?

Cannabicyclol (CBL) is one of non-psychoactive cannabinoid found in the cannabis plant, meaning it does not produce the “high” associated with THC. It is formed through the degradation of other cannabinoids, primarily cannabichromene (CBC). When CBC is exposed to light and heat, it can convert to CBL.

Unlike the more well-known cannabinoids such as THC (tetrahydrocannabinol) and CBD (cannabidiol), CBL is less studied and not as well understood.

The Research on Cannabicyclol (CBL)

Cannabicyclol (CBL) is among the least studied cannabinoids. The research history of Cannabicyclol (CBL) is relatively limited, especially compared to more extensively studied cannabinoids such as THC and CBD. However, there have been some notable events in the history of CBL research:

  1. Discovery and Initial Characterization: CBL was first discovered by Raphael Mechoulam’s Israeli team of cannabis researchers in 1966. Early studies primarily focused on identifying and classifying the various cannabinoids found in cannabis, with researchers working to understand their chemical structures and basic properties.
  2. Understanding the Formation of CBL: Researchers found that CBL is not typically present in fresh cannabis plants. Instead, it forms as a degradation product of other cannabinoids, primarily cannabichromene (CBC). When CBC is exposed to light and heat, it can convert to CBL, indicating that CBL is more likely to be found in aged or improperly stored cannabis.

Potential Effects and Benefits

The potential effects and benefits of Cannabicyclol (CBL), a lesser-known cannabinoid found in the cannabis plant, remain largely speculative due to limited research. However, we can explore what is known and hypothesize based on preliminary studies and the effects of similar cannabinoids:

Known Effects of CBL

Like many other cannabinoids, CBL is non-psychoactive, meaning it does not produce the “high” associated with THC.

One study carried out on rabbits in 1976 showed that a dose of 8 mg/kg of CBL produced seizures and resulted in the death of one rabbit. However, this study was small and did not offer any firm conclusions regarding using CBL in humans.

Potential Benefits

Given the therapeutic benefits observed in other cannabinoids like CBD and CBC, researchers speculate that CBL might possess similar properties. These could include anti-inflammatory, analgesic (pain-relieving), or neuroprotective effects. However, these effects have not been directly observed or studied in CBL.

Some preliminary studies or anecdotal evidence may suggest potential therapeutic roles for CBL. These could range from helping to alleviate certain types of pain to potential roles in treating specific medical conditions. However, without robust clinical trials, these remain largely hypothetical.

Within the context of the “entourage effect,” where different cannabinoids and terpenes in cannabis work together to produce unique effects, CBL could play a synergistic role when combined with other cannabinoids. This potential synergy might enhance the therapeutic effects of cannabis extracts that contain CBL.


To better understand the unique character of CBL, let’s compare it to other cannabinoids:


Despite sharing the trait of being non-psychoactive, CBL and CBD seem to have limited similarities. These two cannabinoids originate from distinct pathways within the hemp plant: CBD is formed from CBGa through CBDa, whereas CBL is indirectly produced as a byproduct of CBC.


Similarly, the connection between CBG (Cannabigerol) and CBL (Cannabicyclol) appears to be somewhat distant. CBG is a direct derivative of CBGa (Cannabigerolic acid), placing it just one step away from the primary cannabinoid precursor. In contrast, CBL is several steps further down the line in the cannabinoid family tree. The potential benefits of both CBG and CBL could overlap in ways that aren’t yet clear. As we deepen our understanding of CBL’s impact on the human body, these parallels may become more evident.


CBL and CBT share a closer relationship compared to many other cannabinoids, primarily because their origins trace back to CBC (Cannabichromene). The process of transformation is distinct for each: CBL is formed when CBC is oxidized, undergoing a chemical change due to exposure to oxygen. On the other hand, CBT comes into being through an enzymatic reaction involving CBC. Much like CBL, the potential benefits and applications of CBT remain to be fully uncovered by future research. Given the growing interest and popularity in cannabinoids, it’s highly likely that both CBL and CBT will be subjects of more in-depth studies in the near future. This increasing focus on cannabinoid research promises a better understanding of these substances and their possible uses.


Cannabicyclol (CBL) and cannabichromene (CBC) are both minor cannabinoids, but with key differences. CBL is a breakdown product of CBC, formed through oxidation, similar to how CBN comes from THC. While CBC shows promise in pain relief, inflammation reduction, and potential anti-cancer properties, CBL research is in its early stages, with few known effects beyond potentially influencing the entourage effect in cannabis synergy. Think of CBC as the active player and CBL as a supporting character with less defined, but potentially interesting, roles.


CBL significantly differs from THC in both its development and effects. These two compounds arise through distinct processes as the cannabis flower matures, and it’s improbable that CBL and THC share any major similarities in their impact. As for CBL’s specific effects, they remain largely unknown, but it’s highly doubtful that this cannabinoid causes any intoxicating effects.

CBL in Vaping: Prospects and Challenges

The use of Cannabicyclol (CBL) in vaping products presents both exciting prospects and notable challenges. On one hand, incorporating CBL into vaping options could broaden the range of cannabinoid-based products, attracting users keen to explore alternatives to the more common THC and CBD offerings. This expansion is particularly appealing if CBL is found to have therapeutic benefits, as vaping is a method known for its quick delivery system, potentially offering health advantages without the psychoactive impact associated with THC.

On the other hand, the primary hurdle in utilizing CBL for vaping lies in the current lack of comprehensive research about its effects, especially when inhaled. This gap in knowledge raises concerns about the safety, effectiveness, and appropriate dosage of CBL in a vaping context. Furthermore, developing vaping products that include CBL would require meticulous formulation to ensure the compound’s stability and efficacy. This process is complicated by the often strict and intricate regulatory environment surrounding cannabis-derived products, which can pose additional challenges in bringing CBL vaping products to market.


Cannabicyclol (CBL) is a lesser-known, non-psychoactive cannabinoid, formed as a byproduct of CBC degradation under certain conditions. Its effects and potential benefits are not as well studied as those of THC or CBD, leaving much about CBL speculative. While preliminary research suggests possible therapeutic applications, much remains to be discovered about CBL’s role in cannabis’s complex interplay of compounds and its potential contributions to health and wellness.

Ethan Parker
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