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Cannabicyclolic Acid (CBLA)

Ethan Parker

Written by: Ethan Parker

Updated on December 23, 2023

Cannabicyclolic Acid (CBLA)

When it comes to cannabinoids, there are few that are more mysterious than CBLA. Since it was discovered in 1972, we have learned very little about it. In this guide, we’ll break down what we do know about this elusive cannabinoid and answer the questions:

What is Cannabicyclolic Acid (CBLA)?

Cannabicyclolic acid (CBLA) is the acidic precursor of the cannabinoid cannabicyclol (CBL), formed during the photochemical reaction of cannabichromenic acid (CBCA). It is a non-toxic cannabinoid that differs from primary cannabinoids such as tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA).

Unlike these original cannabinoids, CBLA does not derive directly from cannabis but rather forms under specific reaction conditions and environments. For instance, exposure to ultraviolet (UV) light or high temperatures triggers the decomposition of CBCA, leading to the conversion of CBCA into CBLA, with a molecular formula of C22H30O4. Consequently, since its first isolation in 1972, researchers have classified CBLA as a synthetic product.

Potential Uses and Benefits

CBLA and CBL do not directly interact with the endocannabinoid system (ECS) by binding to cannabinoid receptors 1 or 2 (CB1 or CB2). However, CBLA may engage in synergistic effects by binding with other cannabinoids, terpenes, and flavonoids, promoting entourage effects.

While research on CBLA is still in its early stages, there is growing interest in its potential uses and benefits. Some studies suggest that CBLA may possess anti-inflammatory, antimicrobial, and antioxidant properties, similar to other acidic cannabinoids found in the cannabis plant. The compound is thought to undergo chemical transformations, particularly through the photochemical reaction of cannabichromenic acid (CBCA) in response to factors like ultraviolet (UV) light or heat.

As research continues, a better understanding of CBLA’s therapeutic potential and its possible applications in areas such as inflammation management and overall health and wellness may emerge. However, it’s important to note that more research is needed to fully elucidate the extent of CBLA’s benefits and mechanisms of action.

Potential Risks and Side Effects

Research on the effects of CBLA, including any risks or adverse impacts is limited. Studies have found that the decarboxylated form of CBL, known as CBL, can induce seizures in rabbits at a dose of 8 milligrams per kilogram. However, this is a small-scale study, and there is no evidence to suggest that such an occurrence might take place in humans. It’s important to note that cannabinoids may have antiepileptic effects in humans.


To better understand the unique character of CBT, let’s compare it to other cannabinoids:


Cannabicyclolic acid (CBLA) and cannabicyclol (CBL) are like a before-and-after duo in the cannabis world. CBLA is the acidic precursor to CBL, meaning it’s the early, inactive form that transforms into the more familiar CBL through decarboxylation, a process that loses a carbon dioxide molecule. Think of it like an unripe apple turning sweet and mellow as it ripens. Both CBLA and CBL hold potential for various therapeutic effects, but CBL generally seems to be the more active and researched of the two. So, next time you see “CBL” on a cannabis product, remember that it might have started its journey as the less-sung hero, CBLA.


Both CBLA and CBD are cannabinoids found in cannabis, but they differ in important ways. CBLA is the precursor to CBD, meaning it transforms into CBD during the drying and curing process. CBD is much more abundant and studied, while CBLA remains less understood but potentially holds unique therapeutic properties due to its acidic form. Think of CBLA as the raw, unactivated potential, and CBD as the unlocked, active form with known benefits.


While both CBLA and THC are cannabinoids found in cannabis, they differ significantly: CBLA is a non-psychoactive precursor molecule to THC, meaning it doesn’t get you “high.” It requires exposure to sunlight or heat to convert into THC, which is the main psychoactive component responsible for the euphoric effects. Think of CBLA as the unactivated form, waiting for its moment to shine (or decarboxylate) as THC.

Where Can You Find CBLA?

Due to its rarity, products rich in Cannabicyclolic Acid (CBLA) simply do not exist. Instead, it’s advisable to purchase cannabis products, such as flower, which may contain trace amounts of CBLA. While it may not have any overt effects, it still presents an intriguing and unique way to experience the myriad cannabinoids present in the cannabis plant. However, it is recommended to consult specialized cannabis dispensaries or companies focused on unique cannabinoid formulations, and always ensure compliance with local regulations.

Ethan Parker
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